These data were formatted for fitting the random encounter model to estimate seasonal densities of coyotes (Canis latrans) and black-tailed jackrabbits (Lepus californicus) in the Mojave Desert, USA. Data were collected from 40 camera-traps that were randomly placed with respect to coyote and/or jackrabbit sign (e.g., tracks, scat, direct observations) and 43 camera-traps that were strategically placed where coyote and/or jackrabbit sign existed. Data were collected within and adjacent to the Boulder City Conservation Easement, Nevada, USA, during 2019-2021.