The water-quality data contained in this data release was collected in support of a project conducted by the U.S. Bureau of Reclamation (BOR), U.S. Geological Survey (USGS), U.S. Environmental Protection Agency (USEPA), University of Oklahoma, and City of Norman. This multiagency study was conducted to provide information on the use of constructed wetlands to support indirect potable reuse to achieve water supply augmentation from reuse of both treated effluent and stormwater runoff at a BOR project (Norman Project, Lake Thunderbird) in central Oklahoma. On May 9th, 2022, a parcel-tracking sampling approach was employed to collect municipal sewage samples at the untreated screened influent location and seven locations within a pilot-scale advanced-treatment process that included enhanced biological nutrient removal (BNR) and advanced wastewater treatment (AWT) processes. Additional standard-treated sewage effluent samples were collected at the same wastewater treatment plant (Norman Water Reclamation Facility) during wet (May 10, 2022) and dry periods (August 9, 2022, and April 17, 2024). In addition to the various municipal sewage samples, potential effluent-receiving surface water and urban stormwater runoff samples were collected. The potential effluent-receiving surface-water site (upper Dave Blue Creek) was sampled three times, twice during base flow (June 28, 2022, and April 16, 2024) and once during high flow (September 2, 2022) conditions. One urban stormwater runoff sample was collected on September 1, 2022. All water samples were collected and analyzed for an extensive suite of 551 organic chemicals (e.g., artificial sweeteners, disinfection byproducts, hormones, per and polyfluoroalkyl substances, pesticides, pharmaceuticals, polycyclic aromatic hydrocarbons, quaternary ammonium compounds, and wastewater compounds), 65 inorganics (e.g., nutrients, trace metals, rare-earth metals), 12 water properties, and 19 bacterial parameters.