USGS Isotope is a database of radiogenic and stable isotopic data from rocks and critical mineral deposits. The data set contains published elemental concentrations, isotopic ratios, analytical information, sample metadata including location, and source citations. The following analytical techniques are represented in the data set: Sm-Nd, U-Th-Pb, Rb-Sr, Lu-Hf, Re-Os, O, and S. This data set incorporates data from published journal articles, geological survey reports, and data releases. These data are primarily from the United States, but data from other parts of North America are also included. This is part of an ongoing effort and the dataset will be expanded and updated regularly.