The U.S. Geological Survey (USGS) developed high-resolution orthomosaics from natural color aerial photographs collected by the Civil Air Patrol (CAP) of 45-60 km of the North Santiam River in the Willamette River Basin in Oregon in 2022 and 2023. Aerial photographs were collected between September 14 and September 22, 2022, from Detroit Lake to Stayton, and again between July 7 and July 13, 2023, from Detroit Lake to the confluence with the Willamette River, from a Cessna 182 aircraft with a Waldo Air XCam Ultra 50 imaging system, which consists of two oblique-mounted Canon EOS 5DS R cameras that are triggered simultaneously. The aerial photographs captured an approximately 1.5-2.5 kilometer-wide area, generally parallel to and including the North Santiam River. The USGS applied photogrammetry to the aerial photographs to produce orthomosaic imagery with approximately 10-centimeter spatial resolution. This data release includes the unprocessed aerial photographs, processed orthomosaics, and an orthomosaic index shapefile. The orthomosaic files are formatted as Cloud-Optimized Geotifs (COGs) with JPEG compression to enable cloud-based access. The following documentation describes the 2022 orthomosaics. This work was conducted in cooperation with the U.S. Army Corps of Engineers and as part of the USGS Next Generation Water Observing System (NGWOS) to support hydrogeomorphic analyses and water availability studies.