This data set contains various reported age determinations from various rock types collected from the larger region surrounding and including the islands of the Greater Antilles and United States Territory of Puerto Rico. Although a select few of the samples were collected as part of geological mapping and research conducted and funded by the Mineral Resources Program of the U.S. Geological Survey in 2018, most samples reported here were collected and analyzed by numerous diverse agencies and laboratories. Data from nineteen different types of analysis methods are reported here in an attempt to show age determinations and relationships from various rock types represented across the broad region of the islands and seafloor of the Caribbean Sea and associated regions.