Since its formation, the Colorado River Basin Salinity Control Forum and its partners have completed a substantial amount of work in an ongoing effort to reduce salinity concentrations and loads in the Colorado River. These efforts and related monitoring have generated a large volume of data and information. This U.S. Geological Survey data release includes geospatial datasets that provide information on salinity-related topics and research in the Colorado River Basin. The datasets include background information and study-specific information. These datasets can be viewed in the accompanying interactive map, available at https://usgs.maps.arcgis.com/apps/webappviewer/index.html?id=a9728bc71f854e7da3e79632441b48a7.