This data release contains Mann-Kendall trend results (p-values and Theil-Sen slope values) of water use data in either 8-digit Hydrologic Unit Code (HUC08) or Van Metre hydrologic regions across the conterminous United States (CONUS) for the period 2000-2020. Trends are computed for 7 timesteps: annual, winter (Dec, Jan, Feb), spring (Mar, Apr, May), summer (Jun, Jul, Aug), fall (Sep, Oct, Nov), high (Apr-Sep), and low (Oct-Mar) from three monthly HUC12 water-use datasets: public supply (Luukkonen, and others, 2023), irrigation (Martin, and others, 2023; Haynes and others, 2023), and thermoelectric (Galanter, and others, 2023; Gorman and others, 2023). Trends are computed on withdrawals, consumptive use, and the ratio of consumptive use to total withdrawal types for each of the three water use categories. In addition, trends were calculated for all withdrawals across the three categories (summing HUC12 datasets). Trends in thermoelectric data and all withdrawals are limited to the period 2008-2020. In addition to the trends data in “trends_modelled_wateruse.csv”, this dataset includes several files in the “trends.zip” folder that were used to download modelled output data, calculate trends (volumetric and Regional Kendall), and visualize trends across water-use categories and hydrologic units.