In cooperation with the South Carolina Department of Transportation, the U.S. Geological Survey updated the foundational geospatial layers for the South Carolina StreamStats web application (https://water.usgs.gov/osw/streamstats/), which provides analytical tools useful for water-resources planning and management (Kolb and others, 2018). This dataset presents the digital elevation model, lidar-derived flow direction, flow accumulation, and percent basin slope raster data layers used for analysis in StreamStats. It also includes the streamline vector data used to hydro-enforce the raster data layers.