The goal of this study was to develop and examine whether a management bait that can be used for selective control of grass carp. Our objectives were to 1) quantify the water-based 24-h LC50 of Antimycin-A for grass carp and rainbow trout, 2) quantify the 96-h LD50 of orally administered Antimycin-A laden bait for grass carp and rainbow trout, 3) quantify the leaching rate of Antimycin-A from the bait in water, and 4) determine if a management bait laden with Antimycin-A will be consumed by grass carp and cause lethality in the laboratory. To meet our objectives, Antimycin-A was encapsulated in a wax microparticle similar to Poole et al. (2018) and incorporated into a rapeseed bait for oral gavage feeding and consumption trials to demonstrate if Antimycin-A can be orally delivered, protected from degradation, and readily consumed by grass carp. The dataset includes raw files of toxicity survival information, water quality, bait leaching, and Antimycin-A analytical measurements.