The California State Water Resources Control Board (State Water Board) initiated the Oil and Gas Regional Monitoring Program (RMP) to assess effects of oil and gas development on groundwater designated for any beneficial use. The U.S. Geological Survey (USGS) is the technical lead in conducting the RMP through the California Oil, Gas, and Groundwater (COGG) Program, working in cooperation with the State Water Board, and in partnership with other State and local agencies. The USGS collected and analyzed groundwater and associated quality control (QC) samples for an RMP study of the Santa Fe Springs (SFSP) Oil Field during April 2021 through April 2024. Groundwater samples collected in 2021-2024 were from twenty-seven monitoring wells, two irrigation wells, three public supply wells and a fire hydrant located within the Santa Fe Springs Oil Field study area. Samples were collected using established groundwater data-collection protocols and procedures. Samples were analyzed for water-quality indicators, major and minor ions, nutrients, trace elements, volatile organic compounds (VOCs), naturally-occurring radioactive material, geochemical and age-dating tracers, dissolved organic carbon (DOC) characteristics, dissolved standard and hydrocarbon gases, and dissolved noble gases and atmospheric gases. In total, 261 constituents, water-quality indicators, or properties were measured. QC samples analyzed for the Santa Fe Springs Oil Field study area include five field blanks, one equipment blank, six VOC source solution blanks, four replicates, and four VOC spikes.