Streamflow and stream temperature in the Donner und Blitzen River Basin for water years 1980 through 2021 were simulated using the Precipitation-Runoff Modeling System (PRMS) with the "stream_temp" module. The model domain was discretized into 175 stream segments and calibrated to observed streamflow and stream temperature at points distributed throughout the basin. Model input files, including a PRMS control file, parameter file, and meteorological forcing files, are included in the Blitzen_PRMS_input.zip file. Select output variables for each hydrologic response unit (HRU), each stream segment, and PRMS basin summary outputs are included in the Blitzen_PRMS_output.zip file. Shapefiles of the model domain, model components, and observation points are contained in the Blitzen_PRMS_GIS.zip file. Streamflow and stream temperature are important components of fish growth potential and the model output contained here can support distributed fish bioenergetics models and drought assessment within the Donner und Blitzen River Basin.