This study evaluated the use of medicated feeds to treat furunculosis infections caused by the bacterium Aeromonas salmonicida in lake herring (Coregonus artedi, Lesueur, 1818). The objectives of this two-phase study were to (1) determine if Coregonus artedi could be adequately and consistently infected with A. salmonicida by the methods of bath immersion or intraperitoneal (IP) injection, and (2) determine if the medicated feeds Oxytetracycline Dihydrate (Terramycin® 200 For Fish) and Florfenicol (Aquaflor®) could be used for the control of furunculosis caused by A. salmonicida. These datasets include water quality, mortality, feed weights and behavior, and qPCR data collected during both phases of the study.