The U.S. Geological Survey (USGS), in cooperation with the Wyoming Water Development Office, developed streamflow statistics for active (through September 30, 2021) and discontinued USGS streamgages in and near Wyoming with 10 or more years of daily mean streamflow record. The computation of streamflow statistics for USGS streamgages is part of a larger study to develop a StreamStats application (www.usgs.gov/streamstats) for the State of Wyoming (https://www.usgs.gov/centers/wyoming-montana-water-science-center/science/wyoming-streamstats). StreamStats is a web-based computer program that can be used to delineate drainage areas, determine basin characteristics, and compute streamflow statistics at locations with and without streamgages (https://streamstats.usgs.gov/ss/; Ries and others, 2024). Streamflow at each streamgage was assessed for degree of human alteration owing to dams and diversions before streamflow statistics were computed. Streamflow records from 631 streamgage periods of record were used to compute basic, seasonal, and flow-duration statistics; records for 390 streamgage periods of record were used to compute n-day statistics and statistics that can be used for regional regression. Methods used to compute the summary statistics contained in this data release are described in an accompanying report (Armstrong and others, 2025).