This dataset contains quality assurance sample concentrations for 19 constituents for the 15 monitored watersheds in Gwinnett County, Georgia, from 2000 to 2020. Samples include 431 replicate pairs and 335 field blanks. Replicate sampling allows for comparison of water quality to assess the combined variability in sample representativeness and laboratory precision and can also be used to identify possible sample contamination. Field blanks, samples of deionized “blank” water collected using the same sampling equipment and similar methodology as routine samples, were used to identify any possible contamination from field collection equipment and methodology.