Various water column variables, including salinity, dissolved inorganic nutrients, pH, total alkalinity, dissolved inorganic carbon, radio-carbon isotopes were measured in samples collected using a Niskin-bottle rosette at selected depths from sites offshore of California and Oregon from October to November 2019 during NOAA Ship Lasker R-19-05 (USGS field activity 2019-672-FA). CTD (Conductivity Temperature Depth) data were also collected at each depth that a Niskin-bottle sample was collected and are presented along with the water sample data. This data release supersedes version 1.0, published in August 2020 at https://doi.org/10.5066/P9ZS1JX8. Versioning details are documented in the accompanying VersionHistory_P9JKYWQU.txt file.