This U.S. Geological Survey (USGS) data release provides a digital geospatial database for the geologic map of Precambrian metasedimentary rocks of the Medicine Bow Mountains, Albany and Carbon Counties, Wyoming (Houston and Karlstrom, 1992). Attribute tables and geospatial features (points, lines and polygons) conform to the Geologic Map Schema (GeMS, 2020) and represent the geologic map plates as published at a scale of 1:50,000. The 358,697-acre map area includes the geologically complex Medicine Bow Mountains located 30 miles (48 kilometers) west of Laramie in southeastern Wyoming. References: Houston, R.S., and Karlstrom, K.E., 1992, Geologic map of Precambrian metasedimentary rocks of the Medicine Bow Mountains, Albany and Carbon Counties, Wyoming: U.S. Geological Survey, Miscellaneous Investigations Series Map I-2280, scale 1:50,000, https://doi.org/10.3133/i2280. U.S. Geological Survey National Cooperative Geologic Mapping Program, 2020, GeMS (Geologic Map Schema) - A standard format for the digital publication of geologic maps: U.S. Geological Survey Techniques and Methods, book 11, chap. B10, 74 p., https://doi.org//10.3133/tm11B10.