This data release is a compilation of published and unpublished thermal maturity and source rock geochemical data (Rock-Eval, pyrolysis) from subsurface wells in the Permian Basin, west Texas and southeast New Mexico. These data include 67 newly collected samples and analyses from Delaware Basin wells (identified as Cicero_2022), as well as 1028 previously unpublished USGS analyses from the entire province (identified as LIMS). Data were also synthesized from publicly available sources, such as theses and dissertations, state agencies and databases, as well as from the body of published literature.