This dataset contains the concentration and quality assurance results for inorganic and organic analytes collected for the U.S. Geological Survey (USGS), Ecosystems Mission Area, Environmental Health Infrastructure Program, Tapwater Exposure Project conducted in Minnesota, in August of 2019. Samples were obtained from multiple publicly distributed water sources in Minnesota in 2019. Due to privacy concerns, the exact location where samples were collected are not reported and station identification numbers have been anonymized. Water-quality samples were analyzed for pesticides, pharmaceuticals, volatile organic compounds and per- and polyfluoroalkyl substances at the USGS National Water Quality Laboratory (NWQL), Denver, Colorado; disinfection byproducts were analyzed at the USGS Organic Chemistry Research Laboratory (OCRL), Sacramento, California; inorganic analytes (cations, anions, nitrate, and trace elements) were analyzed at the USGS Redox Chemistry Laboratory (RCL), Boulder, Colorado; cyanotoxins were analyzed at the USGS Organic Geochemistry Research Laboratory (OGRL), Lawrence, Kansas. Water samples for bioassay analyses (estrogen, androgen, and glucocorticoid receptor) were extracted at the OGRL and analyzed at the U.S. Environmental Protection Agency, Durham, North Carolina.