Despite its subdued expression and isolated location within the Great Plains of southeastern Colorado, the 80-km-long Cheraw fault may be one of the most active faults in North America east of the Southern Rocky Mountains. We present geomorphic analyses, geochronology, and paleoseismic trenching data to 1) document the rupture history of the ~45-km-long southwestern section of the Cheraw fault over the past ~19 ka, and 2) evaluate slip-rate changes for the entire fault over the past ~200 ka. Results from new trenches excavated at the Old Ranch site show evidence of four surface-rupture events since ~19 ka, each with an average vertical displacement of 0.75 m. An additional event is likely only slightly older than ~19 ka. Evidence for relatively small displacements at and near the Old Ranch site suggests that most of these earthquakes were M 7 or less and likely did not rupture the full length of the Cheraw fault. Since ~19 ka, the average slip rate is ~0.16 mm/yr near the Old Ranch site with an average interevent time of 3 - 5 kyr. New geochronologic data for mid- to late Quaternary geomorphic surfaces cut by the Cheraw fault imply rapid incision by local Arkansas River tributaries from ~145 ka to ~100 ka. Maximum vertical offsets of 7 to 9 m for these surfaces indicate that from ~19 to >200 ka the average slip rate was no greater than ~0.03 mm/yr. The accelerated slip rate since ~19 ka suggests a possible response to rapid erosional unloading and/or a limited late Cenozoic, <40 kyr, paleoseismic history for the Cheraw fault.