This dataset documents the depth to groundwater measured in wells screened in the Chicot aquifer, Evangeline aquifer, Jasper aquifer, Burkeville confining unit, Catahoula confining system, or a combination of multiple hydrogeologic units in the greater Houston area, Texas for 2021. The U.S. Geological Survey prepared this dataset in cooperation with the Harris‐Galveston Subsidence District, City of Houston, Fort Bend Subsidence District, Lone Star Groundwater Conservation District, and Brazoria County Groundwater Conservation District. This dataset was created to provide resource managers, public officials, researchers, and the general public with ready access to information regarding depths to groundwater in the region. All of the data in this dataset were collected from November 2020 through March 2021 and are stored in the National Water Information System (NWIS), a publicly available, searchable, online database of water information (http://doi.org/10.5066/F7P55KJN). These digital data accompany a U.S. Geological Survey Scientific Investigation Report by Braun and Ramage (2021).