A series of linear regression models were developed and calibrated for two Lower Minnesota River sites. The linear regression models were either calibrated using acoustic or streamflow data to estimate suspended-sediment or sand concentration data. Data were collected during calendar years 2012 through 2019. The estimates of suspended-sediment and concentrations from the linear regression were used to calculate loads. The calibrated models were used to improve understanding of sediment and sand transport processes and increase accuracy of estimating sediment and sand concentrations and loads for the Lower Minnesota River, as part of the associated report, U.S. Geological Survey Open File Report 2021–1005 (https://doi.org/10.3133/ofr20211005).