This tabular data set represents the percent of land cover classes from the new generation of the 2016 National Land Cover Datasets for the years 2001, 2004, 2006, 2008, 2011, 2013, and 2016 compiled for two spatial components of the NHDPlus version 2.1 data suite (NHDPlusv2) for the conterminous United States; 1) individual reach catchments and 2) reach catchments accumulated upstream through the river network. This dataset can be linked to the NHDPlus version 2 data suite by the unique identifier COMID. The source data is the "NLCD 2016 Land Cover Conterminous United States" datasets for the years 2001, 2004, 2006, 2008, 2011, 2013, and 2016 produced by the United States Geological Survey (Yang and others, 2018). Units are percent. The "NLCD 2016 Land Cover Conterminous United States" datasets (NLCD 2016) are a 16-class (additional four classes in Alaska only) land cover classification scheme that has been applied consistently across all 50 United States and Puerto Rico at a spatial resolution of 30 meters. Reach catchment information characterizes data at the local scale. Reach catchments accumulated upstream through the river network characterizes cumulative upstream conditions. Network-accumulated values are computed using two methods, 1) divergence-routed and 2) total cumulative drainage area. Both approaches use a modified routing database to navigate the NHDPlus reach network to aggregate (accumulate) the metrics derived from the reach catchment scale. (Schwarz and Wieczorek, 2018). First posted: January 20, 2020. Revised: January 25, 2021.