This 3D voxel model of density in GOCAD format was used to study crustal architecture beneath the Southern Midcontinent (USA) by McCafferty and others (2019). The study covered a rectangular, multi-state area of 924 by 924 kilometers centered on Missouri, and a corresponding volume extending from the topographic surface to a depth of 50 kilometers below sea level. The 3D voxel model describes the density of the crust and upper mantle as interpreted using 3D inversion. The masked version excludes densities in areas where the Precambrian basement surface elevations are unknown. The individual voxel elements are 2,000 by 2,000 meters by 500 meters thick. Missing data nodes are assigned a value of -99999.