Understanding how ecological and cultural resources may change in the future is an important component of conservation planning and for the implementation of long-term environmental monitoring. We modeled six future scenarios of urbanization and sea level rise to investigate their potential effects on the Peninsular Florida Landscape Conservation Cooperative's Priority Resources (PFLCC 2016), which were identified as important for conservation through a cooperative multi-partner effort to prioritize conservation efforts on a state-wide scale. These data represent conservation targets for the Coastal Uplands at present, and under six future scenarios of sea level rise and urbanization.