The dataset catalogs and describes existing online, federally supported databases and tools dealing with various aspects of a potential national Early Detection and Rapid Response (EDRR) invasive species framework. This dataset is supplementary material 2 and 3 to the manuscript, "Envisioning a national invasive species information framework" (Reaser et al., 2020) published as part of a special open source issue dealing with invasive species early detection and rapid response by the journal Biological Invasions, Volume 22, Issue 1, January 2020 (https://link.springer.com/journal/10530/22/1). A user-friendly version of this dataset is also available online as a USGS Library Guide, here: https://libraryguides.usgs.gov/edrrinvasive