This data release documents water-quality data obtained as part of an assessment of compounds of emerging concern (CECs) measured in samples collected at potable water and wastewater treatment plants in Dallas and downstream from Dallas in the Trinity River from August 2009 to December 2013 by the U.S. Geological Survey in cooperation with the City of Dallas, Dallas Water Utilities. Targeted CECs (120 total) included human-health pharmaceuticals (prescription and non-prescription), antibiotics, steroidal hormones, stanols, sterols, detergents, personal-use products (flavors and fragrances), pesticides and repellents, industrial wastewater compounds, disinfection compounds, PAHs, flame retardants, and plasticizers. Water samples were collected at three PWTP sites, two WWTP sites, and five study sites on the Trinity River; all sites where samples were collected were in or downstream from Dallas. Additionally, bed-sediment samples were collected at each of the five Trinity River sites. There were 57 targeted CECs in bed-sediment samples. These data were used in a companion report to assess occurrence, distribution, and fate of the analyzed compounds.