Airborne hyperspectral image data from the upper Sacramento River in northern California were acquired on September 14, 2017 to support research on remote sensing of rivers, particularly retrieval of water depth, and to facilitate efforts to characterize salmon habitat conditions and geomorphic change along the upper Sacramento River. These data were collected by the Compact Airborne Spectrographic Imager (CASI) 1500H, manufactured by ITRES Research Limited. The flight was conducted by Quantum Spatial, Inc. (QSI); QSI also performed the initial radiometric and geometric data processing. The data were acquired from fixed wing aircraft and have a spatial resolution (pixel sizes) of 0.5 m. The data set consists of 48 spectral bands spanning the visible and near infrared wavelength range from 0.373 - 1.043 micrometers. Atmospheric correction and reflectance retrieval were performed by QSI using the ATCOR4 software package. The image pixel values represent reflectance with a scale factor of 10,000 and are stored as 16-bit signed integers. The image data file has a band sequential (BSQ) interleave and is in an ENVI-compatible *.bsq file format with an associated header (*.hdr) text file. The image provided in this data release is a subset focused on the reach of the Sacramento River where it is joined by its tributary Cottonwood Creek. Supporting field data from this reach were collected in coordination with the acquisition of the remotely sensed data.