This CSV file contains landscape factors representing anthropogenic disturbances to stream habitats summarized within local and network stream catchments as well as 90 m local and network buffer of stream reaches throughout the conterminous U.S. The source datasets compiled and attributed to spatial units were identified as being: (1) meaningful for assessing fluvial fish habitat; (2) consistent across the entire study area in the way that they were assembled; (3) broadly representative of conditions in the past 10 years, and (4) of sufficient spatial resolution that they could be used to make valid comparisons among local catchment units. Variables summarized at the catchment scale include measures of anthropogenic land uses, population density, roads, dams, mines, water withdrawals, sediment and nutrient loading to rivers, and point-source pollution sites, whereas buffers were attributed with only land use variables. In this data set, variable summaries are linked to catchments and buffers developed for the National Hydrography Dataset Plus Version 1 (NHDPlusV1) using the COMID identifier. Catchment attributes are available for both local catchments (defined as the land area draining directly to a reach; attributes begin with "L_" prefix) and network catchments (defined by all upstream contributing catchments to the reach's outlet, including the reach's own local catchment; attributes begin with "N_" prefix). Like the catchment variables the buffer variables are labeled using a LB and NB prefix for local buffer and network buffer variables, respectively.