This USGS data release contains 2013 streamflow, baseflow, and precipitation data from three hydrologically-diverse streams in the United States used to develop a conceptual framework for effectively anticipating water-quality changes resulting from changes in agricultural activities. The framework combined generalized concepts on the movement of water, the environmental behavior of chemicals and eroded soil, and the designed functions of various agricultural activities. The framework addresses the impacts on water quality of a broad range of agricultural chemicals and sediment across a variety of hydrologic settings. • Chesterville Branch near Crumpton, Maryland, (USGS site ID - 01493112) had substantial baseflow throughout the year with increased streamflow within a day of rainfall. • Indian Creek at State Line RD, Leawood, Kansas (USGS site ID - 06893390) was a fastflow-dominated urban steam that was not well connected to shallow groundwater. • The watershed of Leary-Weber Ditch at Mohawk, Indiana (USGS site ID - 03361638) has an extensive subsurface drainage network within its watershed. These data support the following publication: Capel, P.D., Wolock, D.M., Coupe, R.H., and Roth, J.L., 2017, A conceptual framework for effectively anticipating water-quality changes resulting from changes in agricultural activities: U.S. Geological Survey Scientific Investigations Report 2017-5095, 35 p., https://doi.org/10.3133/sir20175095.