A three-dimensional, groundwater-flow model developed by Halford and Jackson (https://doi.org/10.3133/pp1863) was used to simulate effects of future (2020—2120) groundwater pumping on water levels and natural discharges in the Alkali Flat–Furnace Creek Ranch (AFFCR), Ash Meadows, Pahute Mesa–Oasis Valley (PMOV), and Pahrump to Death Valley South (PDVS) groundwater basins, southern Nevada and California. Four pumping scenarios were simulated, including a base case and scenarios A, B, and C. Scenarios were simulated from 1913 to 2120, with historical pumping occurring from 1913 to 2010, historical 2010 pumping rates projected from 2010 to 2020, and scenario pumping beginning in 2020. The base case projected 2010 pumping rates from 2010 to 2120, and scenarios A, B, and C projected base case pumping plus additional pumping at various locations from 2020 to 2120. Input and output files for the predictive simulations are in the model and output directories, respectively. This USGS data release contains model files for the simulations and analysis results described in U.S. Geological Survey Scientific Investigations Report 2020-5103 (https://doi.org/10.3133/sir20205103). A detailed description of model development and calibration is documented in U.S. Geological Survey Professional Paper 1863 (https://doi.org/10.3133/pp1863).