The surface elevation table (SET)-marker horizon (MH) approach (SET-MH, together) is a method for quantifying surface elevation change through measurements of surface and subsurface processes that control wetland soil elevation. This dataset combines SET-MH data from five different U.S. Geological Survey efforts to monitor surface elevation change in the coastal wetlands of the Greater Everglades region of south Florida. Data from these efforts have been used in the publications by Cahoon and Lynch (1997), Whelan et al. (2005, 2009), Smith et al. (2009), McKee (2011), Breithaupt et al. (2020), Feher et al. (2020), Howard et al. (2020), and Osland et al. (2020). Although some of these data have previously been released on ScienceBase as individual datasets (see Feher et al. 2019, Howard et al. 2019, Cormier et al. 2020, and Lynch et al. 2020), the dataset presented here combines these individual data releases into one single product and also includes new data that were collected after the original release of these data. These data were combined with additional SET-MH data provided by collaborators at the South Florida Water Management District, Florida International University, U.S. Fish and Wildlife Service, and U.S. National Park Service to provide a regional synthesis of available data regarding surface elevation change dynamics in coastal wetlands of the Greater Everglades.